Craniomandibular Osteopathy (CMO) – Terrier Type
Kodas: H312
Short description
Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a developmental bone disorder that causes bony lesions on the skull.
General information
Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a developmental bone disorder that causes bony lesions on the skull. Occurring in West Highland White Terriers, Scottish Terriers and Cairn Terriers, it is caused by a dominant mutation with incomplete penetrance to the Solute Carrier Family 37 Member 2 (SLC37A2) gene.
Because of its occurance in the West Highland White Terrier, the disorder is also known as Westie Jaw.
A closely related variant of the disorder is found in the Basset Hound.
Specifications
| Breeds | Cairn Terrier, Scottish Terrier, West Highland White Terrier |
|---|---|
| Gene | SLC37A2 |
| Chromosome | 5 |
| Mutation | c.1332C>T |
| Organ | Skeletal system |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Dominant with Incomplete Penetrance |
| Also known as | CMO |
Clinical features
CMO begins manifesting in affected dogs between 4 and 8 months of age. Signs include swelling of the jaw, difficulty opening the jaw, pain, a lack of apetite and periodic fever. Bony lesions develop on the skull, mainly on the jawbone. Symptoms usually recede when the dog has finished its growth period.
References
Pubmed ID: 27187611
Year published: 2016
Omia ID: 2244
Omia variant ID:
Turnaround information
- 10 working days