Macular Corneal Dystrophy (MCD)
Kodas: H317
Short description
Macular Corneal dystrophy (MCD) is an eye condition in Labrador Retrievers that causes the corneas to gradually become cloudy, leading to worsening vision.
General information
Macular Corneal dystrophy (MCD) is an eye condition in Labrador Retrievers that causes the corneas to gradually become cloudy, leading to worsening vision. It is most likely caused by a recessive mutation in a comparative candidate gene (CHST6), which is also called LOC489707.
Specifications
| Breeds | |
|---|---|
| Gene | LOC489707 |
| Chromosome | 5 |
| Mutation | c.814C>A |
| Organ | Sensory organs |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | MCD |
Clinical features
Onset of MCD is generally between 4.5 and 6 years of age. The cornea becomes gradually cloudy, and develops multiple off-white to yellow-brown opaque spots of varying sizes. Affected dogs may show signs of impaired vision, though complete blindness is generally uncommon.
References
Pubmed ID: 26585178
Year published: 2016
Omia ID: 2071
Omia variant ID:
Turnaround information
- 10 working days