Von Willebrand Disease Type 2-2
Kodas: H345
Short description
Von Willebrand disease II (vWD Type 2-2) is a hereditary bleeding disorder.
General information
Von Willebrand disease II (vWD Type 2-2) is a hereditary bleeding disorder. It result from a lack or reduced level of a blood clotting protein called von Willebrand factor (vWF). The Age of onset is variable, some dogs only become obvious “bleeders” later in life.
Specifications
| Breeds | Chinese Crested, Boykin Spaniel, German Shorthaired Pointer, German Spitz, German Wirehaired Pointer |
|---|---|
| Gene | VWF |
| Chromosome | 27 |
| Mutation | c.1657T>G |
| Organ | Cardiovascular System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | vWD II |
Clinical features
Symptoms vary from easy bruising, asymptomatic to spontaneous bleeding and prolonged bleeding after injury, surgery or giving birth. In case of surgery the veterinarian should be informed. Affected dogs may also need close monitoring during their daily lives. Without medical intervention, uncontrolled bleeding can lead to death.
References
Pubmed ID: 28696025
Year published: 2017
Omia ID: 1339
Omia variant ID:
Turnaround information
- 10 working days