Intestinal Cobalamin Malabsorption (ICM, IGS) – Beagle
Kodas: H366
Short description
Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption (ICM), is a disorder in which the intestines fail to absorb enough Vitamin B12.
General information
Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption (ICM), is a disorder in which the intestines fail to absorb enough Vitamin B12. This variant, found in the Beagle, is caused by a recessive mutation to the gene CUBN. Similar variants also occur in the Border Collie and Komondor.
Specifications
| Breeds | |
|---|---|
| Gene | CUBN |
| Chromosome | 2 |
| Mutation | c.786delC |
| Organ | Digestive System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | I-GS |
Clinical features
Symptoms for dogs affected by IGS can include lethargy, poor apetite and discomfort after eating, which can additonally result in in poor growth and/or weight loss. Urinary analysis may also reveal increased protein levels in the urine.
References
Pubmed ID: 24164695
Year published: 2014
Omia ID: 1786
Omia variant ID:
Turnaround information
- 10 working days