Hereditary Nephritis (HN) – Samoyed
Kodas: H370
Short description
Canine Hereditary Nephritis (HN) is a group of hereditary glomerular diseases of the kidneys, which often progress to renal failure.
General information
Canine Hereditary Nephritis (HN) is a group of hereditary glomerular diseases of the kidneys, which often progress to renal failure. X-linked nephritis is caused by mutations in the alpha 5 chain of collagen type IV (COL4A5). This variant of the disorder is found in the Samoyed. A related variant has also been observed in the Navasota dog.
Specifications
| Breeds | |
|---|---|
| Gene | COL4A5 |
| Chromosome | X |
| Mutation | c.3079G>T |
| Organ | Respiratory System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | X-Linked |
| Also known as | HN |
Clinical features
Clinical signs include for affected dogs include proteinuria and the development of rapidly progressive renal failure. The symptoms are usually fatal before 1 year of age. Approximately 31% of the carrier female Samoyeds develop mild renal disease, and 38% progress to the final stage of the renal disease.
References
Pubmed ID: 8171024
Year published: 1994
Omia ID: 1112
Omia variant ID:
Turnaround information
- 10 working days