Sensory Neuropathy – Border Collie
Kodas: H388
Short description
Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene.
General information
Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene. Animals with the disease show degeneration of sensory nerve cells and motor nerve cells.
This variant is for the Border Collie.
Specifications
| Breeds | |
|---|---|
| Gene | FAM134B |
| Chromosome | 4 |
| Organ | Nervous System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | SN |
Clinical features
The first clinical signs of SN present between 2 and 7 months of age. The first visible signs are progressive proprioceptive ataxia with intermittent "knuckling" of the paws, hyperextension of the limbs, and self-mutilation wounds on and around the paws. Generally, the hind limbs are more severely affected than the front limbs. Later stages can also involve loss of sensation, and urinary incontinence.
Additional information
Other/mixed breeds with border collie ancestors can also be affected.
References
Pubmed ID: 27527794
Year published: 2016
Omia ID: 2032
Omia variant ID:
Turnaround information
- 15 working days