Hypotrichosis and Short Life Expectancy – Cat
Kodas: K390
Short description
In the Birman cat breed, a hereditary disorder has been observed that results in hypotrichosis (loss of hair) and thymic aplasia (an underdeveloped thymus), resulting in a drastically lowered life expectancy.
General information
In the Birman cat breed, a hereditary disorder has been observed that results in hypotrichosis (loss of hair) and thymic aplasia (an underdeveloped thymus), resulting in a drastically lowered life expectancy. The disorder is caused by a recessive mutation to the gene FOXN1.
Specifications
| Breeds | |
|---|---|
| Gene | FOXN1 |
| Chromosome | E1 |
| Mutation | c.1030_1033delCTGT |
| Organ | Integumentary System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
Clinical features
Affected kittens are born hairless, and only develop a sparse and shortened coat, as well as wrinkled and greasy-seeming skin. They are prone to infections of the airways, digestive system and skin. Survival past the age of 8 months is unlikely, and euthanasia on humane grounds is likely to be considered.
References
Pubmed ID: 25781316
Year published: 2015
Omia ID: 1949
Omia variant ID:
Turnaround information
- 10 working days