Leukoencephalomyelopathy (LEMP) – Leonberger
Kodas: H892
Short description
Leukoencephalomyelopathy (LEMP) is a severe, degenerative neural disorder that occurs in young dogs and causes a progressive loss of muscle coordination.
General information
Leukoencephalomyelopathy (LEMP) is a severe, degenerative neural disorder that occurs in young dogs and causes a progressive loss of muscle coordination. The disorder is caused by a recessive mutation to the gene NAPEPLD. The variant of LEMP analysed in this test occurs in the Leonberger. A related variant is found in the Great Dane and Rottweiler.
Specifications
| Breeds | |
|---|---|
| Gene | NAPEPLD |
| Chromosome | 18 |
| Mutation | c.538G>C |
| Organ | Nervous System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | LEMP |
Clinical features
Onset of LEMP symptoms in affected dogs generally occurs between 1 and 2 years of age. Signs include ataxia (loss of coordination), knuckling and dragging of the paws, hypermetria (overextension of limbs while stepping) and reduced spinal reflexes. The disease progresses over a matter of months, and euthanasia on humane grounds is likely to be considered.
References
Pubmed ID: 29643404
Year published: 2018
Omia ID: 1788
Omia variant ID:
Turnaround information
- 10 working days