Haemophilia A – Rhodesian Ridgeback
Kodas: H931
Short description
Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs.
General information
Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery. This specific variant of the disease occurs in the Rhodesian Ridgeback. Related variants are also found in the Irish Setter and Miniature Schnauzer, Boxer, Old English Sheepdog, and the German Shepherd.
Specifications
| Breeds | |
|---|---|
| Gene | F8 |
| Chromosome | X |
| Mutation | c.4824_25ins221 |
| Organ | Cardiovascular System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | X-Linked Recessive |
| Also known as | FVIII |
Clinical features
Common clinical signs in dogs included: bleeding from the mouth, subcutaneous and intramuscular haematomas and lameness.
References
Pubmed ID: 33494213
Year published: 2021
Omia ID: 437
Omia variant ID:
Turnaround information
- 10 working days