Haemophilia A – Boxer
Kodas: H877
Short description
Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs.
General information
Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery.
The specific variant of the disease analysed in this test is found in the Boxer. Related variants are also found in the Irish Setter and Miniature Schnauzer, German Shepherd, Old English Sheepdog, and the Rhodesian Ridgeback.
Specifications
| Breeds | |
|---|---|
| Gene | F8 |
| Chromosome | X |
| Mutation | c.1412C>G |
| Organ | Cardiovascular System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | X-Linked Recessive |
| Also known as | FVIII |
Clinical features
Common clinical signs in dogs include bleeding from the mouth, subcutaneous and intramuscular haematomas and lameness.
References
Pubmed ID: 25040606
Year published: 2014
Omia ID: 437
Omia variant ID:
Turnaround information
- 10 working days