Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) – Labrador Retriever
Kodas: H283
Short description
Dyserythropoietic Anaemia and Myopathy Syndrome (DAMS) is a severe blood and muscle disorder in dogs.
General information
Dyserythropoietic Anaemia and Myopathy Syndrome (DAMS) is a severe blood and muscle disorder in dogs. The disorder causes muscle atrophy, anaemia, heart defects, and may result in the death of affected puppies. It is caused by a recessive mutation to the gene EHBP1L1, and is found in the Labrador Retriever. A closely related variant of the disorder occurs in the English Springer Spaniel.
Specifications
| Breeds | |
|---|---|
| Gene | EHBP1L1 |
| Chromosome | 18 |
| Mutation | c.388C>T |
| Organ | Cardiovascular System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | DAMS |
Clinical features
Affected dogs present with blood abnormalities such as microcytosis, which can be identified through veterinary blood analysis. Other symptoms of the disorder can include weakness of the hind limbs, vomiting, weight loss and muscle atrophy.
References
Pubmed ID: 36011338
Year published: 2022
Omia ID: 2564
Omia variant ID:
Turnaround information
- 10 working days